The goal of C3P research is to improve the care and outcomes of children at high risk of tumor development. We welcome additional research collaborations; to discuss potential collaboration, please contact us and/or complete C3P’s project proposal form (see also C3P’s publication policy).

The C3P has identified several research priorities for patients with cancer predisposition syndromes (CPS) and their families. These include:

• Improved identification of children with CPS
• Optimization of tumor surveillance
• Characterization of tumor biology in the setting of CPS
• Understanding the psychosocial impacts of CPS

Childhood Cancer Predisposition Study

The Childhood Cancer Predisposition Study (CCPS) is a multi-center, longitudinal, observational registry and biorepository. CCPS is open for enrollment at C3P member sites for children under age 18 with a cancer predisposition.

The primary objectives of CCPS are to:

• Establish and maintain a framework for recruitment, participation, and surveillance of children with CPS in clinical and translational research studies
• Define the natural history of disease in children with CPS
• Evaluate the clinical impact and effectiveness of standard and emerging tumor surveillance strategies

Collaborators

Data for the Common Good (D4CG) https://commons.cri.uchicago.edu/pcdc/

The Pediatric Cancer Data Commons (PCDC) is the flagship project of D4CG. The PCDC houses the world’s largest set of harmonized clinical data for pediatric cancer research. With hundreds of international collaborators forming more than 10 disease-specific consortia, PCDC has collected and harmonized data from across more than 40 countries and almost all types of pediatric cancer and continues to grow. C3P has worked with the PCDC to harmonize data elements and share data collected through the Childhood Cancer Predisposition Study.

KPS Registry (German pediatric cancer predisposition registry) https://www.krebs-praedisposition.de/en/

With the collaboration of the Clinic for Pediatric Hematology and Oncology at the Hannover Medical School and the Hopp Children’s Tumor Center (KiTZ) Heidelberg, the research registry for cancer predisposition syndromes (KPS Registry) was opened in August 2017.

The KPS Registry aims to learn more about cancer predisposition syndromes, share findings with specialists and those affected, and achieve better medical and psychosocial care for people with cancer predisposition syndromes.